The Chicago Cubs took a big step in their bid to win a series over a plus-.500 team for the first time since they won both games over the Los Angeles Dodgers in April.

Miles Mikolas allowed six home runs vs. Cubs and made Cardinals history in a disastrous Fourth of July loss at Wrigley Field.

The Cubs lost their third straight, tying a season high. Lars Nootbaar gave the Cardinals a 2-0 lead with a two-run homer in the second and Winn hit a two-run homer in the third.

BOTTOM LINE: The Chicago Cubs take on the St. Louis Cardinals after Michael Busch hit three home runs on Friday in an 11-3 win over the Cardinals. Chicago is 53-35 overall and 29-15 in home games.

Cubs take series and open up a 6½-game lead with a thunderous shutout, the Cardinals’ fourth shutout loss in their past six games. Cubs clobber Cardinals, 11-0, as Erick Fedde’s problems ...

Cubs vs. Cardinals Betting Insights This season, the Cubs have been favored 62 times and won 43, or 69.4%, of those games. Chicago has a record of 9-1, a 90% win rate, when favored by -220 or more ...

Cubs Make History Against Cardinals on Fourth of July originally appeared on Athlon Sports. The Chicago Cubs are 52–35 and in sole possession of first place in the NL Central as they head into a ...

St. Louis has a 47-41 record overall and a 21-24 record in road games. The Cardinals have the 10th-ranked team ERA in the NL at 3.94. Friday’s game is the fifth time these teams match up this ...

The Cubs’ Michael Busch hits a two-run home run against the Cardinals during the third inning Friday, July 4, 2025, in Chicago. It was one of three homers on the day for Busch.

BOTTOM LINE: The Chicago Cubs take on the St. Louis Cardinals after Michael Busch hit three home runs on Friday in an 11-3 win over the Cardinals. Chicago is 53-35 overall and 29-15 in home games.

Cubs vs. Cardinals Betting Insights The Cubs have been favorites in 61 games this season and won 43 (70.5%) of those contests. Chicago has a record of 14-4 in games when oddsmakers favor them by ...