Why do some people age rapidly while others maintain their health well into their 80s and 90s? A new study suggests that maintaining “youthful” organs may be key. Scientists led by Tony Wyss-Coray at ...

Is Alzheimer’s disease different in people with Down’s? Two recent proteomics studies say yes. In the July 1 Nature Communications, scientists led by Erik Johnson at Emory University School of ...

κWhen microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

Nowadays, in the hunt for biomarkers of Alzheimer’s and related diseases, blood is where it’s at. Blood draws are cheaper and easier than other options, and clinical trial participants prefer them, ...

While biomarkers have transformed Alzheimer’s research, much work remains to be done to develop these important tools for other neurodegenerative diseases, not to mention for the concurrent ...

CagA disrupts bacterial biofilms. It also prevents Aβ and α-synuclein from forming fibrils. Scientists will test CagA in AD and PD mouse models to assess its therapeutic potential. Scientists estimate ...

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Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

TDP-43 Conference Marks Concerted Effort to Finally Snag Biomarkers Add To My AlzForum 30 Jun 2025 Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders.