A 26-year-old man who had emigrated from Nepal 7 years earlier presented with ankle swelling, cough, unintentional weight loss, and a leg rash. A chest radiograph showed hilar lymphadenopathy.

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc ...

In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 2).

The U.S. Supreme Court recently upheld Tennessee’s ban on gender-affirming hormonal treatment for transgender minors. This decision will have profound implications.

In 2006, a prospective observational study first showed that physical activity after a colon cancer diagnosis was linked to a decreased risk of recurrence and death.1 Since then, numerous observati ...

A 51-year-old man presented with a 3-month history of weight loss, diarrhea, and fever. Transthoracic echocardiography showed vegetations on the aortic and mitral valves. A duodenal biopsy showed p ...

In the current anti-immigrant political environment in the United States, what will happen when immigrants who work in the health care system are forced to leave?

Cardiovascular diseases, principally ischemic heart disease and stroke, have consistently been the leading cause of death worldwide since 1990 and accounted for 19.8 million deaths in 2022 alone.1 ...

Audio Interview from the New England Journal of Medicine — Interview with Patricia Mae Santos on the effects of U.S. anti-immigrant policies on immigrant health care workers and their patients.

A 59-year-old man presented with a 5-hour history of severe, pleuritic chest pain after vomiting. CT of the chest revealed air in the mediastinum extending up to the neck and perforation of the eso ...